Beta Klotho Protein, Mouse, Recombinant (His)

Catalog No. TMPK-01150

Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites. Beta Klotho Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 109.91 kDa and the accession number is Q99N32-1.

Beta Klotho Protein, Mouse, Recombinant (His)

Catalog No. TMPK-01150

Pack Size	Price	Availability
100 μg	$511	In Stock
500 μg	$2,040	7-10 days
1 mg	$3,410	7-10 days

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Product Information

Biological Activity	Human FGFR4, hFc Tag captured on CM5 Chip via Protein A can bind Mouse Beta Klotho, His Tag with an affinity constant of 36.97 nM as determined in SPR assay.
Description	Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites. Beta Klotho Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 109.91 kDa and the accession number is Q99N32-1.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q99N32-1
Synonyms	β-klotho,βKlotho,β Klotho,MGC142213,klotho β like,Klotho β,klotho beta like,Klotho beta,KLB,BKL,beta-klotho,betaKlotho
Construction	Phe53-Pro994
Protein Purity	> 90% as determined by Tris-Bis PAGE; > 90% as determined by HPLC
Molecular Weight	109.91 kDa (predicted). Due to glycosylation, the protein migrates to 120-130 kDa based on Tris-Bis PAGE result.
Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Stability & Storage	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Shipping with blue ice.
Research Background	Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.