Immobilized CCR5 Protein-Nanodisc, Human, Recombinant (Flag-Strep & His) (Cat#TMPY-07105) at 5 μg/mL (100 μL/well) can bind Leronlimab-Derived Anti-CCR5 Antibody, Human IgG1, the EC50 is 10-32 ng/mL.

CCR5 Protein-Nanodisc, Human, Recombinant (Flag-Strep & His) is expressed in HEK293 Cells. The accession number is P51685.

Human

HEK293 Cells

IDDM22,CMKBR5,CKR-5,CKR5,CD195,CCR-5,CC-CKR-5,CCCKR5

A DNA sequence encoding the Human CCR5 (P51685)(Met1-Arg223) & (Glu227-Arg319) was expressed and linked by a Fusion Protein, with a Flag and a polyhistidine tag at the N-terminus. Within the expressed regions, there are several proprietary thermostabilizing mutations.This protein was prepared using our Nanodisc platform. Nanodisc is a versatile tool for studying membrane proteins. Using styrene-maleic acid (SMA) copolymer, membrane proteins can be extracted directly from prokaryotic and eukaryotic expression systems in the absence of detergents to preserve the protein structure and function better. Compared to membrane scaffold proteins (MSPs) nanodiscs, SMA nanodiscs also have the advantage of preserving proteins' nature by maintaining native lipids surrounded without introducing any heterologous proteins, which allows studies of protein structure and functions in a native-like environment.

≥ 90% as determined by SDS-PAGE.

Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.