CD84 Protein, Human, Recombinant (His)

Pack Size	Price	Availability	Quantity
100 μg	$398	7-10 days
1 mg	$2,590	7-10 days

Pack Size

Price

Availability

Quantity

100 μg

$398

7-10 days

1 mg

$2,590

7-10 days

QWhether recombinant proteins be available?

AWhat species of protein do you need, and do you have any requirements for expression systems and tags? What experiments will the product be used for?

QWhy are carrier proteins needed in some recombinant protein solutions?

ACarrier proteins help improve the stability of proteins and prevent them from adhereing to the walls upon freeze and thaw. If proteins adhere to the tube, it will lead to a decrease in protein concentration in the solution which affects protein activity. For long term storage, carrier proteins, such as 0.1% Bovine Serum Albumin (BSA), 5% Human Serum Albumin (HAS), 10% Fetal Bovine Serum (FBS), or 5% trehalose, are used to reduce such loss. If the concentration of the recombinant protein is low, please add an appropriate amount of carrier protein to maintain protein activity.

QHow are recombinant protein products shipped?

AMost recombinant proteins are delivered as lyophilized powder, which are insensitive to temperature change and are stable at room temperature. They are typically shipped at room temperature or with blue ice. For liquid recombinant proteins, dry ice is generally used for shipping. It is normal if the product is arrived with a melted ice pack. The protein can still be used without any negative impact on its quality for a short period. If a specific protein is unstable at room temperature, appropriate cold chain shipping will be arranged to ensure product quality remains intact.

QCan protein activity be guaranteed?

AFor our in-stock products, activity data will be displayed on our official website. However, the absence of data does not mean there is no activity. It could be that we have not yet established an activity detection method or conducted testing. Nevertheless, our products are prioritized for expression and purification using methods known to retain activity.

QWhy is the volume & weight of the product not as expected?

AThe lyophilized powder is obtained from the freeze-drying of protein solutions, and its weight is not equivalent to that of protein. The volume of powder is influenced by different factors, including the composition of the buffer prior to lyophilization, salt ion concentration, and the concentration of the product itself. Thus, it’s normal that the powder may appear plentiful or be skipped by the eye. Upon receiving the product, proceed with reconstitution, use, or aliquot storage as usual.

Biological Activity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	CD84 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9UIB8-3.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q9UIB8-3
Synonyms	SLAMF5,mCD84,LY9B,hCD84,CD84 molecule
Construction	A DNA sequence encoding the extracellular domain (Met 1-Gly 225) of human CD84 (NP_003865.1) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Lys 22
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	24 kDa (predicted); 45 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. The CD84-CD84 interaction was independent of its cytoplasmic tail. Thus, CD84 is its own ligand and acts as a costimulatory molecule. CD84 is expressed on cells from almost all hematopoietic lineages and on CD34+ hematopoietic progenitor cells, suggesting that CD84 serves as a marker for committed hematopoietic progenitor cells.

CD84 Protein, Human, Recombinant (His)

CD84 Protein, Human, Recombinant (His)

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