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CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 45.3 kDa and the accession number is Q60737.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μg | $498 | 7-10 days |
Biological Activity | Kinase activity untested |
Description | CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 45.3 kDa and the accession number is Q60737. |
Species | Mouse |
Expression System | Baculovirus Insect Cells |
Tag | Tag Free |
Accession Number | Q60737 |
Synonyms | Csnk2a1-rs4,CK2 α/CSNK2A1,casein kinase 2, α1 polypeptide,casein kinase 2, alpha 1 polypeptide |
Construction | A DNA sequence encoding the mouse CAMK4 CSNK2A1 (Q60737) (Met1-Gln391) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus. Predicted N terminal: Gly |
Protein Purity | > 90 % as determined by SDS-PAGE |
Molecular Weight | 45.3 kDa (predicted); 40 kDa (reducing conditions) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.4. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | Shipping with blue ice. |
Research Background | Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Casein kinase II (CSNK2A1) is a constitutively active, ubiquitously expressed serine / threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CSNK2A1 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CSNK2A1, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CSNK2A1 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CSNK2A1 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt. |
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