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ECM1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q16610-1.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | $539 | Backorder | |
1 mg | $3,480 | Backorder |
Biological Activity | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
Description | ECM1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q16610-1. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-His |
Accession Number | Q16610-1 |
Synonyms | URBWD |
Construction | A DNA sequence encoding the human ECM1 isoform 1 (NP_004416.2)(Met 1-Glu 540) was expressed with a C-terminal polyhistidine tag. |
Protein Purity | ≥ 90% as determined by SDS-PAGE |
Molecular Weight | 60.2 kDa (predicted); 80-90 kDa (reducing contition, due to glycosylation) |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Lyophilized from sterile PBS, pH 7.2. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
Reconstitution | Please refer to the lot-specific COA. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | Extracellular matrix protein 1 (ECM1) is a secreted glycoprotein and playing a pivotal role in endochondral bone formation, angiogenesis, and tumour biology. Three splice variants have been identified: ECM1a (540 aa) is most widely expressed, with highest expression in the placenta and heart; ECM1b (415 aa) is differentiation-dependent expressed and found only in tonsil and associated with suprabasal keratinocytes; ECM1c (559 aa) accounts for approximately 15% of skin ECM1. Although ECM1 is not tumor specific, is significantly elevated in many malignant epithelial tumors and is suggested as a possible trigger for angiogenesis, tumor progression and malignancies. It also has been shown to regulate endochondral bone formation, skeletal development and tissue remodeling. |
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