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Fractalkine Protein, Canine, Recombinant

Catalog No. TMPY-03898

Fractalkine Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.2 kDa and the accession number is H1ADY9.

Fractalkine Protein, Canine, Recombinant

Fractalkine Protein, Canine, Recombinant

Catalog No. TMPY-03898
Fractalkine Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.2 kDa and the accession number is H1ADY9.
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50 μg$4627-10 days
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Product Information

Biological Activity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Fractalkine Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.2 kDa and the accession number is H1ADY9.
Species
Canine
Expression System
HEK293 Cells
TagTag Free
Accession NumberH1ADY9
Synonyms
chemokine (C-X3-C motif) ligand 1
Construction
A DNA sequence encoding the canine CX3CL1 (H1ADY9) (Met1-Arg379) was expressed with six amino acids (LEVLFQ) at the C-terminus. Predicted N terminal: Gln 25
Protein Purity
> 95 % as determined by SDS-PAGE
Molecular Weight38.2 kDa (predicted); 64-69 kDa (reducing conditions)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.

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Please read the User Guide of Recombinant Proteins for more specific information.