1. Immobilized GLP1R Protein-Nanodisc, Human, Recombinant (Flag & His) (Cat#TMPY-07122) at 5 μg/mL (100 μL/well) can bind Anti-GLP1R Monoclonal Antibody, Human IgG1, the EC50 is 2-8 ng/mL.
2. Loaded GLP1R Protein-Nanodisc, Human, Recombinant (Flag & His) (Cat#TMPY-07122) on HIS1K Biosensor, can bind Dulaglutide-hIgG4 with an affinity constant of 5.91 μM as determined in BLI assay (Sartorius Octet RED384) (QC tested).

GLP1R Protein-Nanodisc, Human, Recombinant (Flag & His) is expressed in HEK293 Cells. The accession number is P43220.

≥ 90% as determined by SDS-PAGE.

Glucagon-like peptide (GLP)-1 receptor is encoded by GLP1R. GLP1R plays a critical role in mediating the biological actions of GLP1 in mammals and fish. The neuronal GLP1Rs mediate body weight and anorectic effects of liraglutide, but are not required for glucose-lowering effects. Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic properties in animal models and to impact glucose-dependent insulin release, satiety, memory, and learning in man. Glucagon-like peptide-1 receptor (GLP1R) and glucose-dependent insulinotropic peptide receptor (GIPR) are their indirect drug targets.