Immobilized Biotinylated Human GPRC5D-VLP (Full Length) Protein at 5 μg/mL (100 μL/well) on streptavidin precoated (2 μg/well) can bind Anti-Human GPRC5D Antibody, Human IgG1, the EC50 is 4-12ng/mL.

GPRC5D Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.80 kDa and the accession number is Q9NZD1-1.

Human

HEK293 Cells

GPRC5D

Human GPRC5D (Q9NZD1-1) (Met1-Val345)

It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is highly and selectively expressed on the surface of CD138+ multiple myeloma (MM) cells, whereas in normal tissues, a much lower expression is limited to plasma cells and certain hard keratinizing tissues. This makes GPRC5D a promising marker for monitoring tumor load and a target antigen for MM-specific T cell-engaging therapies such as bispecific antibodies and CAR-T cells.