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IL-1F8 Protein, Human, Recombinant (His)

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IL-1F8 Protein, Human, Recombinant (His)

Catalog No. TMPY-02817

IL-1F8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.3 kDa and the accession number is Q9NZH7-2.

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Pack Size	Price	Availability	Quantity
20 μg	$275	7-10 days

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Biological Description

Biological Information	Testing in progress
Description	IL-1F8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.3 kDa and the accession number is Q9NZH7-2.
Species	Human
Expression System	E. coli
Tag	N-His
Accession Number	Q9NZH7-2
Synonyms	FIL1,FIL1H,IL1-ETA,interleukin 36, β,FIL1-(ETA),IL1H2,interleukin 36, beta,IL1F8,IL36B,IL-1F8,FILI-(ETA),IL-1H2
Construction	mature form of Human IL1F8 (NP_775270.1) (Lys 5-Glu 157)
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	19.3 kDa (predicted)
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contain a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includes four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.