IL-22RA1 Protein, Canine, Recombinant (His)

Catalog No. TMPY-04087

IL-22RA1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is A0A8C0M3C4.

IL-22RA1 Protein, Canine, Recombinant (His)

Catalog No. TMPY-04087

IL-22RA1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is A0A8C0M3C4.

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100 μg	$600	7-10 days

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Product Information

Biological Activity	Immobilized canine IL22RA1-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22 , The EC50 of biotinylated IL22 is 0.23-0.55 μg/ml.
Description	IL-22RA1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is A0A8C0M3C4.
Species	Canine
Expression System	HEK293 Cells
Tag	C-His
Accession Number	A0A8C0M3C4
Synonyms	interleukin 22 receptor, α1,interleukin 22 receptor, alpha 1
Construction	A DNA sequence encoding the canine IL22RA1 (XP_855113.2) (Met1-The226) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Ala 15
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	25.6 kDa (predicted); 36 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesions. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22, and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptors for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.