IL-15 Protein, Human, Recombinant

Catalog No. TMPY-04632

IL-15 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.8 kDa and the accession number is P40933-1.

IL-15 Protein, Human, Recombinant

Catalog No. TMPY-04632

IL-15 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.8 kDa and the accession number is P40933-1.

Pack Size	Price	Availability
10 μg	$126	7-10 days
20 μg	$192	7-10 days
50 μg	$329	7-10 days
100 μg	$498	7-10 days
200 μg	$821	7-10 days
500 μg	$2,470	7-10 days

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COA User Guide of Recombinant Proteins

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Product Information

Biological Activity	1. Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 for this effect is typically 0.5-5 ng/mL. 2. Labeled biotin to IL-15 Protein, Human, Recombinant by a certain molar ratio; Using the Octet RED System, the affinity constant (Kd) of IL-15 Protein, Human, Recombinant, Biotinylated bound to Anti-IL15 Antibody was 0.1nM. (Routinely tested)
Description	IL-15 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.8 kDa and the accession number is P40933-1.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P40933-1
Synonyms	interleukin 15,IL-15
Construction	A DNA sequence encoding the human IL15 (NP_000576.1) (Asn49-Ser162) was expressed. Predicted N terminal: Asn 49
Protein Purity	≥ 95 % as determined by SDS-PAGE.
Molecular Weight	12.8 kDa (predicted)
Endotoxin	< 20 EU/mg of the protein.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 200 mM NaCl, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively, spliced transcript variants of this gene have been reported.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy