Immobilized IL-17RA Protein, Human, Recombinant (hFc) (Cat#TMPY-05430) at 2 μg/mL (100 μL/well) can bind IL-17A Protein, Human, Recombinant (Avi & His), Biotinylated (Cat#TMPY-07090) , the EC50 is 4-12 ng/mL.

IL-17A Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 Cells. The accession number is Q16552.

Human

HEK293 Cells

ILA17,IL-17A,IL-17,IL17,CTLA-8,CTLA8

A DNA sequence encoding the Human IL17A (Q16552) (Gly24-Ala155) was expressed with a N-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.

≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC. ≥ 95% as determined by SEC-MALS(Routinely tested).

Please refer to the lot-specific COA.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy