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IL-1 beta/IL-1F2 Protein, Mouse, Recombinant

Catalog No. TMPY-02134
IL-1 beta/IL-1F2 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P10749.
Pack SizePriceAvailabilityQuantity
20 μg$197In Stock
100 μg$4987-10 days
200 μg$8517-10 days
500 μg$2,6907-10 days
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Product Information

Biological Activity
1. Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 6-30 ng/mL.
IL-1 beta/IL-1F2 Protein, Mouse, Recombinant
Description
IL-1 beta/IL-1F2 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P10749.
Species
Mouse
Expression System
E. coli
TagTag Free
Accession NumberP10749
Synonyms
interleukin 1, β,interleukin 1, beta,IL-1β,IL-1beta,Il-1b,IL-1 β
Construction
A DNA sequence encoding the mature form of mouse IL1β (P10749) (Val 118-Ser 269) was expressed, with an initial Met at the C-terminus. Predicted N terminal: Met
Protein Purity
> 97 % as determined by SDS-PAGE
IL-1 beta/IL-1F2 Protein, Mouse, Recombinant
Molecular Weight17.5 kDa (predicted); 19 kDa (reducing conditions)
EndotoxinPlease contact us for more information.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution
Reconstituted with sterile deionized water to 0.25 mg/mL.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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