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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μg | $245 | In Stock | |
100 μg | $416 | 7-10 days | |
200 μg | $704 | 7-10 days | |
500 μg | $1,410 | 7-10 days |
Biological Information | Testing in progress |
Description | IL-23 P19/IL23A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9NPF7. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-hFc |
Accession Number | Q9NPF7 |
Synonyms | IL-23A,IL-23,interleukin 23, alpha subunit p19,SGRF,IL23P19,P19,interleukin 23, α subunit p19 |
Construction | The Human IL23A (NP_057668.1) (Met1-Pro189) was expressed with the Fc region of Human IgG1 at the C-terminus. |
Protein Purity | > 85 % as determined by SDS-PAGE. ![]() |
Molecular Weight | 45.4 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
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