Interferon alpha B/IFNA8 Protein, Human, Recombinant

Catalog No. TMPY-03648

Interferon alpha B/IFNA8 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38 kDa and the accession number is A0A7R8C381.

Interferon alpha B/IFNA8 Protein, Human, Recombinant

Catalog No. TMPY-03648

Interferon alpha B/IFNA8 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38 kDa and the accession number is A0A7R8C381.

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100 μg	$695	7-10 days

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Product Information

Biological Activity	Measured in antiviral assays using WISH cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 0.2-2 pg/mL.
Description	Interferon alpha B/IFNA8 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38 kDa and the accession number is A0A7R8C381.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	P32881
Synonyms	interferon, α8,interferon, alpha 8,Interferon α-B,IFN-αB,IFN-alphaB
Construction	A DNA sequence encoding the human IFNA8 (NP_002161.2)(Cys24-Glu189) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus. Predicted N terminal: Gly
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	38 kDa (predicted); 26 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Interferon alpha-B, also known as IFNA8, belongs to the alpha/beta interferon family. Interferons are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They also allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. Interferons also activate immune cells, such as natural killer cells and macrophages. They increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes. They also increase the ability of uninfected host cells to resist new infections by virus. Certain symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. Produced by macrophages, IFN-alpha has antiviral activities.