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LRP-5 Protein, Human, Recombinant (hFc)

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LRP-5 Protein, Human, Recombinant (hFc)

Catalog No. TMPK-00739

A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 96.51 kDa and the accession number is O75197-1.

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Pack Size	Price	Availability
100 μg	$487	7-10 days
500 μg	$1,950	7-10 days
1 mg	$3,250	7-10 days

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Biological Description

Biological Information	1. Immobilized Human DKK1, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human LPR-5, hFc Tag with the EC50 of 1.04μg/ml determined by ELISA. 2. Human LRP-5, hFc Tag captured on CM5 Chip via Protein A can bind Human DKK1, His Tag with an affinity constant of 0.28 μM as determined in SPR assay.
Description	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 96.51 kDa and the accession number is O75197-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	O75197-1
Synonyms	EVR1,BMND1,BMND1OPTA1,LRP5,LRP7,OPPG,EVR4,OPTA1,OPS,HBM,VBCH2,LR3VBCH2,LRP-7,LR3,LRP-5
Construction	Glu644-Gln1263
Protein Purity	> 95% as determined by Tris-Bis PAGE
Molecular Weight	96.51 kDa (predicted). Due to glycosylation, the protein migrates to 100-115 kDa based on Tris-Bis PAGE result.
Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in PBS, 100 mM L-arginine (pH 7.4).
Stability & Storage	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis.