1.Loaded LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated (Cat#TMPY-07087) on SA Biosensor, can bind DKK1 Protein, Human, Recombinant (His) (Cat#TMPY-00775) with an affinity constant of 90.6 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).
2.Loaded LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated (Cat#TMPY-07087) on SA Biosensor, can bind RSPO1 Protein, Human, Recombinant (His) (Cat#TMPY-01147) with an affinity constant of 4.25 nM as determined in BLI assay (Sartorius Octet RED384) (QC tested).
3.Loaded LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated (Cat#TMPY-07087) on SA Biosensor, can bind SOST/Sclerostin Protein, Human, Recombinant (His) (Cat#TMPY-00925) with an affinity constant of 39.5 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).
4.Loaded LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated (Cat#TMPY-07087) on SA Biosensor, can bind DKK1 Protein, Human, Recombinant (hFc) (Cat#TMPY-05479) with an affinity constant of 54.3 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).

LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 Cells. The accession number is O75581.

≥ 90% as determined by SDS-PAGE.

Lipoprotein receptor-related protein 6 (LRP6) binds to Wnt ligands to transduce signal by stabilization of beta-catenin, which has been involved in the regulation of embryonic development and metabolism. Low density lipoprotein (LDL) receptor-related protein-6 (LRP6) is an important co-receptor of Wnt pathway, which plays a predominant role in the development and progression of colorectal cancer. This gene, termed LDL receptor-related protein 6 (LRP6), encodes a transmembrane protein that has 71% identity and is structurally similar to the protein encoded by LRP5, a proposed candidate gene for type 1 diabetes located on human chromosome 11q13. LRP6 maps to human chromosome 12p11-p13.