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NCAM2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 102.6 kDa and the accession number is O15394-1.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | 570 € | 7-10 days |
Biological Activity | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
Description | NCAM2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 102.6 kDa and the accession number is O15394-1. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-hFc |
Accession Number | O15394-1 |
Synonyms | neural cell adhesion molecule 2,NCAM21 |
Construction | A DNA sequence encoding the human NCAM2 (NP_004531.2) (Met1-Asn697) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu 20 |
Protein Purity | > 95 % as determined by SDS-PAGE |
Molecular Weight | 102.6 kDa (predicted); 112.2 kDa (reducing conditions) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | NCAM2 is a member of the immunoglobulin superfamily of cell adhesion molecules (IgCAMs). The neural cell adhesion molecule 2 (NCAM2) is encoded by a gene on chromosome 21 in humans. Neural cell adhesion molecules 2 (NCAM2/OCAM/RNCAM), is a paralog of NCAM1. The protein exists in transmembrane and a lipid-anchored isoform and has an ectodomain consisting of five immunoglobulin modules and two fibronectin type 3 homology modules. Structural models of the NCAM2 ectodomain reveal that it facilitates cell adhesion through reciprocal interactions between the membrane-distal immunoglobulin modules.NCAM (Neural Cell Adhesion Molecule) proteins are involved in axonal migration, synaptic formation, and plasticity. Poor axonal growth and fasciculation are observed in animal models deficient for NCAM2. |
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