Measured in a cell proliferation assay using MCF-7 cells. The ED50 for this effect is typically 0.1-1 ng/mL.

NRG1 beta 1 Protein, Human, Recombinant (aa 176-246) is expressed in E. coli. The accession number is Q02297-6.

≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.