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NRG1 beta 1 Protein, Human, Recombinant (aa 176-246) is expressed in E. coli. The accession number is Q02297-6.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μg | $150 | Backorder | |
100 μg | $383 | Backorder | |
1 mg | $2,280 | Backorder |
Biological Activity | Measured in a cell proliferation assay using MCF-7 cells. The ED50 for this effect is typically 0.1-1 ng/mL. |
Description | NRG1 beta 1 Protein, Human, Recombinant (aa 176-246) is expressed in E. coli. The accession number is Q02297-6. |
Species | Human |
Expression System | E. coli |
Tag | Tag Free |
Accession Number | Q02297-6 |
Synonyms | SMDF,NRG1-IT2,NDF,MSTP131,MST131,HRGA,HRG1,HRG,HGL,GGF2,GGF,ARIA |
Construction | A DNA sequence encoding the Human NRG1 (Q02297-6) (Thr176-Lys246) was expressed with an N-terminal Met. |
Protein Purity | ≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC. |
Molecular Weight | 8.37 kDa (predicted) |
Endotoxin | < 10 EU per mg of the protein. |
Formulation | Lyophilized from sterile 30% Acetonitrile, 1/1000 TFA. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
Reconstitution | Please refer to the lot-specific COA. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. |
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