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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μg | $383 | 7-10 days | |
1 mg | $3,520 | 7-10 days |
Biological Information | Measured by its binding ability in a functional ELISA. Immobilized Human PDGFRB at 2 μg/ml (100 μl/well) can bind Mouse PDGF-B His, the EC50 of Mouse PDGF-B His is 4-24 ng/mL. |
Description | Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 14.2 kDa and the accession number is Q8R3X9. |
Species | Mouse |
Expression System | P. pastoris (Yeast) |
Tag | N-His |
Accession Number | Q8R3X9 |
Synonyms | platelet-derived growth factor β polypeptide,Sis,platelet-derived growth factor beta polypeptide,PDGF-B |
Construction | Mouse PDGFB (AAH23427.1) (Ser82-Thr190) |
Protein Purity | > 95 % as determined by SDS-PAGE. |
Molecular Weight | 14.2 kDa (predicted) |
Endotoxin | Please contact us for more information. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 30% CAN, 0.1% TFA. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. |
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