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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | $700 | 7-10 days |
Biological Information | Testing in progress |
Description | PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant cell death and maintaining cellular homeostasis. PELI1 might participate in B-cell maturation or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages. |
Species | Human |
Expression System | Baculovirus Insect Cells |
Tag | His, GST |
Accession Number | Q96FA3 |
Synonyms | pellino E3 ubiquitin protein ligase 1,PRISM |
Construction | The Human PELI1 (NP_065702.2) (Met1-Asp418) was expressed with a N-terminal GST-tagged polyhistidine tag at the N-terminus. |
Protein Purity | > 85 % as determined by SDS-PAGE. |
Molecular Weight | 74.1 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant cell death and maintaining cellular homeostasis. PELI1 might participate in B-cell maturation or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages. |
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