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RGMB Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is Q6NW40.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | $687 | Backorder | |
1 mg | $4,560 | Backorder |
Biological Activity | Immobilized BMP4 Protein, Human, Recombinant (E399D) (Cat#TMPY-06842) at 2 μg/mL (100 μL/well) can bind RGMB Protein, Human, Recombinant (hFc) (Cat#TMPY-07146) with a linear range of 0.16-4 ug/mL. |
Description | RGMB Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is Q6NW40. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-hFc |
Accession Number | Q6NW40 |
Synonyms | FLJ90406,DRAGON |
Construction | A DNA sequence encoding the Human RGMB (NP_001012779.2) (Met1-Asn413) was expressed with the Fc region of human IgG1 at the C-terminus. |
Protein Purity | ≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC. |
Molecular Weight | 67.26 kDa (predicted); 63.2 kDa and 20 kDa (reducing contition) |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
Reconstitution | Please refer to the lot-specific COA. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | RGMB was knocked down in breast cancer cells by way of an anti-RGMB ribozyme transgene. Knockdown of RGMB resulted in enhanced capacities of proliferation, adhesion, and migration in breast cancer cells. Further investigations demonstrated RGMB knockdown resulted in a reduced expression and activity of Caspase-3, accompanied with better survival in RGMB knockdown cells under serum starvation, which might be induced by its repression on MAPK JNK pathway. That RGMB may act as a negative regulator in breast cancer through BMP signaling. |
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