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RGMB Protein, Human, Recombinant (hFc)

Catalog No. TMPY-07146

RGMB Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is Q6NW40.

RGMB Protein, Human, Recombinant (hFc)

RGMB Protein, Human, Recombinant (hFc)

Catalog No. TMPY-07146
RGMB Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is Q6NW40.
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100 μg$687Backorder
1 mg$4,560Backorder
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Product Information

Biological Activity
Immobilized BMP4 Protein, Human, Recombinant (E399D) (Cat#TMPY-06842) at 2 μg/mL (100 μL/well) can bind RGMB Protein, Human, Recombinant (hFc) (Cat#TMPY-07146) with a linear range of 0.16-4 ug/mL.
Description
RGMB Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is Q6NW40.
Species
Human
Expression System
HEK293 Cells
TagC-hFc
Accession NumberQ6NW40
Synonyms
FLJ90406,DRAGON
Construction
A DNA sequence encoding the Human RGMB (NP_001012779.2) (Met1-Asn413) was expressed with the Fc region of human IgG1 at the C-terminus.
Protein Purity
≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.
Molecular Weight67.26 kDa (predicted); 63.2 kDa and 20 kDa (reducing contition)
Endotoxin< 1.0 EU per μg protein as determined by the LAL method.
FormulationLyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution
Please refer to the lot-specific COA.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
RGMB was knocked down in breast cancer cells by way of an anti-RGMB ribozyme transgene. Knockdown of RGMB resulted in enhanced capacities of proliferation, adhesion, and migration in breast cancer cells. Further investigations demonstrated RGMB knockdown resulted in a reduced expression and activity of Caspase-3, accompanied with better survival in RGMB knockdown cells under serum starvation, which might be induced by its repression on MAPK JNK pathway. That RGMB may act as a negative regulator in breast cancer through BMP signaling.

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Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.