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S100A3 Protein, Human, Recombinant (His & MBP)

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S100A3 Protein, Human, Recombinant (His & MBP)

Catalog No. TMPY-02222

S100A3 Protein, Human, Recombinant (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 55.3 kDa and the accession number is P33764.

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Pack Size	Price	Availability	Quantity
100 μg	$498	7-10 days

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Biological Description

Biological Information	Testing in progress
Description	S100A3 Protein, Human, Recombinant (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 55.3 kDa and the accession number is P33764.
Species	Human
Expression System	E. coli
Tag	His, MBP
Accession Number	P33764
Synonyms	S100 calcium binding protein A3,S100E
Construction	The Human S100A3 (P33764) (Met 1-Gln 101) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus.
Protein Purity	> 95 % as determined by SDS-PAGE
Molecular Weight	55.3 kDa (predicted)
Endotoxin	Please contact us for more information.
Formulation	Supplied as sterile PBS, 20% glycerol, pH 7.4.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Protein S100-A3, also known as Protein S-100E, S100 calcium-binding protein A3, S100A3 and S100E, is a member of the S-100 family. S100A3 / S100E contains 2 EF-hand domains. S100A3 / S100E is highly expressed in the differentiating cuticular cells within the hair follicle and organized into mature hair cuticles. High concentrations of S100A3 homotetramer might provide the millimolar level of Ca2+required for hair cuticular barrier formation. S100A3 / S100E is a unique member of the Ca2+-binding S100 protein family with the highest cysteine content and affinity for Zn2+. S100A3 / S100E binds both calcium and zinc. S100A3 / S100E probably binds 2 zinc ions per molecule. It may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation. S100A3 plays an important role in calcium-dependent processes leading to hair shaft formation. S100A3 / S100E is a unique protein among all members of the calcium-binding S100 family, is specifically expressed at the inner endocuticle of human hair fibers. Upon hair damage, S100A3 / S100E is released from hair fibers and possibly destabilizes the hair tissue architecture.