Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi)

Catalog No. TMPK-01295

Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.2 kDa and the accession number is XP_005586866.2.

Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi)

Catalog No. TMPK-01295

Pack Size	Price	Availability
100 μg	$487	7-10 days
500 μg	$1,950	7-10 days
1 mg	$3,250	7-10 days

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Product Information

Biological Activity	Immobilized Cynomolgus Siglec-15, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-Siglec-15 Antibody, hFc Tag with the EC50 of 5.6ng/ml determined by ELISA.
Description	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.2 kDa and the accession number is XP_005586866.2.
Species	Cynomolgus
Expression System	HEK293 Cells
Tag	C-His-Avi
Accession Number	XP_005586866.2
Synonyms	SIGLEC-15,Siglec15,HsT1361,CD33L3,CD33 molecule-like 3,CD33 antigen-like 3
Construction	Met60-Thr322
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	29.2 kDa (predicted). Due to glycosylation, the protein migratesto 33-43 kDa based on Tris-Bis PAGE result.
Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in 20 mM PB, 500 mM NaCl, 0.1M L-arginine (pH 6.0).
Stability & Storage	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Shipping with blue ice.
Research Background	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.