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SLC39A6 Protein, Human, Recombinant (HEK293, His) is expressed in HEK293 Cells. The accession number is Q13433-1.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | $617 | Backorder | |
1 mg | $3,930 | Backorder |
Biological Activity | Immobilized SLC39A6 Protein, Human, Recombinant (HEK293, His) (Cat#TMPY-07157) at 2 μg/mL (100 μL/well) can bind Anti-LIV-1 Antibody, the EC50 is 5-15 ng/mL. |
Description | SLC39A6 Protein, Human, Recombinant (HEK293, His) is expressed in HEK293 Cells. The accession number is Q13433-1. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-His |
Accession Number | Q13433-1 |
Synonyms | ZIP6,LIV-1,LIV1 |
Construction | A DNA sequence encoding the Human SLC39A6 (Q13433-1) (Phe29-Trp325) was expressed with a polyhistidine tag at the C-terminus. |
Protein Purity | ≥ 90% as determined by SDS-PAGE. |
Molecular Weight | 35.08 kDa (predicted); 55.2 kDa (reducing contition, due to glycosylation) |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
Reconstitution | Please refer to the lot-specific COA. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. |
Research Background | Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. SLC39A6, also known as LIV-1, belongs to a new subfamily of Zrt, Irt-like protein zinc transporters (LZTs). It is involved in maintaining the intracellular homeostasis of zinc, an ion that is essential in the control of cellular growth and differentiation. SLC39A6 plays a critical role in maintaining zinc homeostasis, and was originally identified as an estrogen-induced gene in a breast cancer cell line. Generally, elevated SLC39A6 expression is reportedly related to cancer progression in other various types of cancer, including breast, prostate, pancreatic, cervical and liver cancers. |
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