Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.

Sortilin/SORT1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q99523-1.

≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.

SORT1 is the neuronal receptor for granulin, encoded by the progranulin gene (GRN), a major causal gene for inherited frontotemporal dementia (FTD). Even though sortilin binds and internalizes LDL by receptor-mediated endocytosis, mutations in the SORT1 gene are unlikely to cause autosomal dominant hypercholesterolemia and may only have a marginal effect on plasma LDL cholesterol levels. The SORT1 locus was originally identified by genome-wide association studies of low-density lipoprotein cholesterol (LDL-C) in adults.