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Sortilin/SORT1 Protein, Human, Recombinant (His)

Catalog No. TMPY-07180

Sortilin/SORT1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q99523-1.

Sortilin/SORT1 Protein, Human, Recombinant (His)

Sortilin/SORT1 Protein, Human, Recombinant (His)

Catalog No. TMPY-07180
Sortilin/SORT1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q99523-1.
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100 μg $687Backorder
1 mg $4,580Backorder
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Product Information

Biological Activity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Sortilin/SORT1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q99523-1.
Species
Human
Expression System
HEK293 Cells
TagC-His
Accession NumberQ99523-1
Synonyms
NTR3,NT3,LDLCQ6,Gp95
Construction
A DNA sequence encoding the Human SORT1 (Q99523-1) (Ser78-Asn755) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity
≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.
Molecular Weight77.20 kDa (predicted); 94.3 kDa (reducing contition, due to glycosylation)
Endotoxin< 1.0 EU per μg of the protein as determined by the LAL method
FormulationLyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution
Please refer to the lot-specific COA.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
SORT1 is the neuronal receptor for granulin, encoded by the progranulin gene (GRN), a major causal gene for inherited frontotemporal dementia (FTD). Even though sortilin binds and internalizes LDL by receptor-mediated endocytosis, mutations in the SORT1 gene are unlikely to cause autosomal dominant hypercholesterolemia and may only have a marginal effect on plasma LDL cholesterol levels. The SORT1 locus was originally identified by genome-wide association studies of low-density lipoprotein cholesterol (LDL-C) in adults.

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Please read the User Guide of Recombinant Proteins for more specific information.