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TCPTP Protein, Human, Recombinant (aa 1-314, His & GST)

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TCPTP Protein, Human, Recombinant (aa 1-314, His & GST)

Catalog No. TMPY-02173

TCPTP Protein, Human, Recombinant (aa 1-314, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 64.4 kDa and the accession number is P17706-1.

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Pack Size	Price	Availability	Quantity
100 μg	$700	7-10 days

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Biological Description

Biological Information	Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate. The specific activity is > 20 nmoles/min/μg.
Description	TCPTP Protein, Human, Recombinant (aa 1-314, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 64.4 kDa and the accession number is P17706-1.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	His, GST
Accession Number	P17706-1
Synonyms	TCPTP,TC-PTP,protein tyrosine phosphatase, non-receptor type 2,PTN2,TCELLPTP,PTPT
Construction	The amino acid (Met 1-Asn 314) of Human PTPN2 (P17706-1) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Protein Purity	> 90 % as determined by SDS-PAGE
Molecular Weight	64.4 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 20 mM Tris, 300 mM NaCl, 10% glycerol, pH 8.0.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein that belongs to the protein-tyrosine phosphatase family and Non-receptor class 1 subfamily. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.