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Recombinant ProteinsOthersTGFBI Protein, Human, Recombinant (His)
TOPBiological Description

TGFBI Protein, Human, Recombinant (His)

TGFBI Protein, Human, Recombinant (His)
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COA

TGFBI Protein, Human, Recombinant (His)

Catalog No. TMPY-01009
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dystrophy. TGFBI can bind to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, TGFBI may be involved in endochondral bone formation. Loss of the TGFBI is sufficient to induce specific resistance.
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Pack SizePriceAvailabilityQuantity
100 μg$386In Stock
200 μg$6607-10 days
500 μg$1,3407-10 days
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Biological Description

Biological Information
Testing in progress
Description
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dystrophy. TGFBI can bind to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, TGFBI may be involved in endochondral bone formation. Loss of the TGFBI is sufficient to induce specific resistance.
Species
Human
Expression System
HEK293 Cells
TagC-His
Accession NumberA0A0S2Z4Q2
Synonyms
CDG2,CSD,EBMD,CSD1,CDGG1,CSD3,transforming growth factor, beta-induced, 68kDa,LCD1,BIGH3,CDB1,transforming growth factor, β-induced, 68kDa,CSD2
Construction
The extracellular domain of Human beta IG-H3 (NP_000349.1) precursor (Met 1-His 683) was expressed, fused with a polyhistidine tag at the C-terminus.
Protein Purity
> 75 % as determined by SDS-PAGE
TGFBI Protein, Human, Recombinant (His)
Molecular Weight74 kDa (predicted)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a sodium citrate buffer system at pH 6. 0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dystrophy. TGFBI can bind to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, TGFBI may be involved in endochondral bone formation. Loss of the TGFBI is sufficient to induce specific resistance.

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Keywords

BIGH-3LCD 1LCD-1transforming growth factor, b-induced, 68kDaCSD-1CSD-2CSD 3CDGG 1CDGG-1CSD 2BIGH 3CDB 1CSD 1CDG 2CSD-3CDG-2CDB-1
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