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VEGFD Protein, Human, Recombinant (His)

Catalog No. TMPY-01008

VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915.

VEGFD Protein, Human, Recombinant (His)

VEGFD Protein, Human, Recombinant (His)

Catalog No. TMPY-01008
VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915.
Pack SizePriceAvailabilityQuantity
10 μg100 €In Stock
20 μg145 €7-10 days
50 μg229 €7-10 days
100 μg328 €7-10 days
200 μg555 €7-10 days
500 μg1.102 €7-10 days
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Product Information

Biological Activity
1.Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC). The ED50 for this effect is 0.3‑1.6 μg/mL. 2.Captured VEGFR3/FLT4 Protein, Human on proA Chip can bind VEGF-D with an affinity constant of 39.03 nM as determined in a SPR assay (Routinely tested).
VEGFD Protein, Human, Recombinant (His)VEGFD Protein, Human, Recombinant (His)
Description
VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915.
Species
Human
Expression System
HEK293 Cells
TagC-His
Accession NumberO43915
Synonyms
VEGF-D,VEGFD,c-fos induced growth factor (vascular endothelial growth factor D)
Construction
A DNA sequence encoding the mature form of human VEGFD (NP_004460.1) corresponding to amino acid (Phe 93-Ser 201) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Phe 93
Protein Purity
> 95 % as determined by SDS-PAGE.
VEGFD Protein, Human, Recombinant (His)
Molecular Weight13.6 kDa (predicted); 20-22 kDa (reducing condition, due to glycosylation)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice.
Research Background
Vascular endothelial growth factor D (VEGF-D), also known as C-fos induced growth factor (FIGF), belongs to the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. FIGF protein is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. FIGF protein is secreted as a non-covelent homodimer in an antiparallel fashion. Human FIGF protein is expressed in adult lung, heart, muscle, and small intestine, and is most abundantly expressed in fetal lungs and skin. FIGF protein is structurally and functionally similar to VEGF-C. Therefore, FIGF protein binds and activates VEGFR-2 (Flk1) and VEGFR-3 (Flt4) receptors, and may particularly be involved in cancers, such as breast cancer, epithelial ovarian carcinoma and so on.

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