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Signaling Pathway Download


Product Name


Diseases and Conditions

T3274 S49076
S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocke... Cancer
T3626 Acalabrutinib
Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosin... Cancer
T3634 AZD-9291 mesylate
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and p... Cancer
T3673 Mollugin
Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocki... Others
T3691 SAR131675
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinas... Others
T3599 BFH772
BFH772, a structure analogue of BAW2881, is a potent and selective VEGF inhibitor. BFH772 ... Immunology
T3641 BAW2881
BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor rece... Others
T3659 AZD3759
AZD3759 is a potent, oral active, central nervous system-penetrant, EGFR inhibitor. At Km ... Cancer
T3024 Avitinib

Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epide...

T7007 UNC-2025
UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM ... Others
T6997 SU6656
SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and... Others
T6996 SU5402
SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 3... Others
T6982 SGI-7079
SGI-7079 ,a novel selective Axl inhibitor, inhibits tumor growth in a dose dependent manne... Others
T6961 PX-478 2HCl
PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibi... Others
T6957 PRT-060318
PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an appro... Others
T6936 PF-03814735
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5... Others
T6933 Peficitinib (ASP015K, JNJ-54781532)
Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3. Others
T6932 PD168393
PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys... Others
T6930 Pazopanib HCl (GW786034 HCl)
Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, ... Others
T6921 ONO-4059 analogue
ONO-4059 analogue is an analogue of ONO-4059, which is a highly potent and selective oral ... Others
T6918 Olmutinib (HM61713, BI 1482694)
Olmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-spe... Others
T6914 Oclacitinib
Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM ... Others
T6908 NSC228155
NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulat... Others
T6838 FLLL32
FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 μM. Others
T6836 FIIN-2
FIIN-2 is an irreversible, pan-FGFR inhibitor with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3... Others
T6824 EAI045
EAI045 is an allosteric inhibitor that targets selected drug-resistant EGFR mutants but sp... Others
T6804 Chetomin
Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1,disrupting the binding ... Others
T6790 BMS-911543
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1?nM, ~350-, 75- and... Others
T6776 BAY-61-3606
BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). Others
T6756 AMG 925
AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and... Others
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