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Signaling Pathway Download

Cat.No.

Product Name

Information

Diseases and Conditions

T6980 Scriptaid
Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3. Others
T3686 10074-G5
The c-Myc oncoprotein is overexpressed in many tumors and is essential for maintaining the... Others
T3186 NU2058
NU2058 is a potent CDK inhibitor that has CDK2 IC(50)=17 microM and CDK1 IC(50)=26 microM.... Cancer
T3346 AKT inhibitor VIII
Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively... Others
T3661 ACY-241
ACY-241, also known as Citarinostat, is a potent, selective and orally available histone d... Cancer
T3664 THZ1
THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) o... Cancer
T3293 Apoptozole
Apoptozole, also known as Apoptosis Activator VII, is a selective inhibitor of heat shock ... Others
T3118 Dimethylenastron
Dimethylenastron is an Eg5 inhibitor, which arrests cells with monopolar spindles to which... Others
T3120 K858
K858 selectively inhibits Eg5 ATPase activity with an IC50 of 1.3 μM. Others
T3132 SC66
SC66 is a novel AKT inhibitor, IC50 values of approximately 0.75 μg/ml at 72 hours in HepG... Others
T3144 Wnt agonist 1 (BML-284)
Wnt agonist 1 is a cell permeable?Wnt?signaling pathway activator, which induces β-catenin... Others
T3638 Leukadherin-1
Allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrin... Others
T3652 KRIBB11
KRIBB11 is an inhibitor of?Heat shock factor (HSF)?inhibitor, with?IC50?of 1.2 μM. Others
T7010 VER155008
VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in c... Others
T7003 TRx0237 (LMTX) mesylate
TRx 0237 (LMTX?) mesylate is a second-generation tau protein aggregation inhibitor for the... Others
T7001 TIC10
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug prop... Others
T6989 SKL2001
SKL2001 is a novel agonist of the Wnt/β-catenin pathway that disrupts the Axin/β-catenin i... Others
T6966 RGD (Arg-Gly-Asp) Peptides
RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins... Others
T6940 PHA-767491
PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 ... Others
T6936 PF-03814735
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5... Others
T6931 PD0166285
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD... Others
T6924 P276-00
P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, resp... Others
T6920 ON123300
ON123300 is a potent and multi-targeted kinase inhibitor with IC50 of 3.9 nM, 5 nM, 26 nM,... Others
T6883 LY3023414
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-... Others
T6868 KYA1797K
KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 μM (TO... Others
T6867 KD025 (SLx-2119)
KD025 is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and ... Others
T6866 K03861
K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2... Others
T6865 Quisinostat (JNJ-26481585) 2HCl
Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest p... Others
T6864 Ixabepilone (BMS-247550)
Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promo... Others
T6849 Uprosertib (GSK2141795)
Uprosertib (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhib... Others
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