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Signaling Pathway Download


Product Name


Diseases and Conditions

T3623 Cobimetinib
Cobimetinib is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) with... Cancer
T3668 Galangin
Galangin has anti-proliferation effect on HCC cells. Galangin elicits anti-inflammatory ef... Others
T3674 Hydroxysafflor yellow A
Hydroxysafflor yellow A inhibited adipogenesis by increasing HSL promoter activities. Hy... Others
T3598 JNK-IN-7
JNK-IN-7 is a selective JNK inhibitor with IC50 values of 1.54 nM, 1.99 nM, 0.75 nM to JNK... Others
T3627 IQ-1S
IQ-1S is a potent and selective c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine d... Others
T7008 Vacquinol-1
Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death. Others
T7005 Ulixertinib (BVD-523, VRT752271)
Ulixertinib (BVD-523, VRT752271) is a potent and reversible ERK1/ERK2 inhibitor with IC50 ... Others
T6976 SB239063
SB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no ac... Others
T6971 RO5126766 (CH5126766)
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 16... Others
T6948 SC1
Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAP... Others
T6934 Pexmetinib (ARRY-614)
Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with... Others
T6927 Pamapimod (R-1503, Ro4402257)
Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated pro... Others
T6895 MLN2480
MLN2480 is an oral, selective pan-Raf kinase inhibitor in chinical trials. Others
T6882 LY3009120
LY03009120 is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf... Others
T6843 GDC-0623
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. Others
T6818 DEL-22379
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ~0.5 μM. Others
T6789 BMS-582949
BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhib... Others
T6785 BI-847325
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with I... Others
T6784 BI-78D3
BI-78D3 is a competitive JNK inhibitor with IC50 of 280nM that displays > 100 fold selecti... Others
T6760 APS-2-79
APS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizin... Others
T6758 Anisomycin
Anisomycin is an antibiotic, which inhibits protein synthesis, and also act as a JNK activ... Others
T0097new MRT67307
MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKε, and NUA... Others
T3544new SHP099 hydrochloride
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC... Others
T3390new Obacunone
Obacunone has cytotoxicity in androgen-dependent human prostate cancer cells. Obacunone e... Others
T3410new Momordin Ic
Momordin Ic might represent a potential anticancer activity, by inducing apoptosis through... Others
T3603new Sodium houttuyfonate
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence related motility of Ps... Others
T3200 DB07268
DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM. Cancer
T3166 VX-11e
VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Sig... Cancer
T3109 SP600125
SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 ... Cancer
T6487 Encorafenib (LGX818)
LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential ant... Cancer