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Signaling Pathway Download


Product Name


Diseases and Conditions

T3156 Ciliobrevin A
Ciliobrevin A is a?hedgehog?(Hh) signaling pathway inhibitor with median inhibitory concen... Others
T3673 Mollugin
Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocki... Others
T3674 Hydroxysafflor yellow A
Hydroxysafflor yellow A inhibited adipogenesis by increasing HSL promoter activities. Hy... Others
T3144 Wnt agonist 1 (BML-284)
Wnt agonist 1 is a cell permeable?Wnt?signaling pathway activator, which induces β-catenin... Others
T3636 SIS3
Selective Smad3 inhibitor; attenuates TGF-β1-dependent Smad3 phosphorylation and DNA bindi... Others
T6995 STA-21
STA-21 is a selective STAT3 inhibitor. Others
T6989 SKL2001
SKL2001 is a novel agonist of the Wnt/β-catenin pathway that disrupts the Axin/β-catenin i... Others
T6935 PF-03084014 (PF-3084014)
PF-03084014 (PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a... Others
T6933 Peficitinib (ASP015K, JNJ-54781532)
Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3. Others
T6914 Oclacitinib
Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM ... Others
T6891 MK-4101
MK-4101, a potent inhibitor of the Hedgehog pathway, shows anti-tumor activity through the... Others
T6870 L-685,458
L-685,458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki... Others
T6868 KYA1797K
KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 μM (TO... Others
T6867 KD025 (SLx-2119)
KD025 is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and ... Others
T6861 IMR-1
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with I... Others
T6838 FLLL32
FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 μM. Others
T6790 BMS-911543
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1?nM, ~350-, 75- and... Others
T6787 BIO-acetoxime
BIO-acetoxime is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity... Others
T3363new Jervine
Jervine's biological activity is mediated via its interaction with the 7 pass trans membra... Others
T3385new Gypenoside XVII
Gypenoside XVII confers protection against Aβ25-35-induced neurotoxicity through estrogen ... Others
T3404new Cucurbitacin B
Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human p... Others
T3620new Solcitinib
Solcitinib, also known as GSK2586184 or GLPG0778, is a Janus kinase 1 (JAK1) inhibitor. So... Immunology
T3380new Homoharringtonine
Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid m... Cancer
T3398new Icaritin
Icaritin has hormone regulation activity and cardiovascular function improvement activity.... Cancer
T2166 TWS119
TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing ... Other
T3280 Disodium clodronate tetrahydrate
Clodronic acid(INN) orclodronate disodium(USAN) is a first generation (non-nitrogenous)?bi... Endocrine system
T2584 Octreotide Acetate
Octreotide is a synthetic long-acting cyclic octapeptide with pharmacologic properties mim... Endocrine system
T1080 Cysteamine
Cysteamine is an agent for the treatment of nephropathic cystinosis and an antioxidant. Other
T3218 Napabucasin
Napabucasin is an orally available Stat3 and cancer cell stemness inhibitor. Other
T6496 EW-7197
EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 in... Immunology
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