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Bcr-Abl
Cat.No. Product Name Information Area
T3196 GNF-7 GNF-7 inhibits Bcr-Abl WT and Bcr-Abl T315I with IC50 of 133 nM and 61 nM, respective... Cancer
T3071 GZD824 GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T... Cancer
T3068 AT9283 AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; a... Cancer
T3063 PD-173955 PD173955 is a potent Bcr-Abl inhibitor with IC50 of 1-2 nM, also inhibiting Src activ... Cancer
T2640 DCC-2036 (Rebastinib) DCC-2036 (Rebastinib) is a conformational control Bcr-Abl inhibitor for Abl1(WT) and ... Cardiovascular System
T2509 Tozasertib VX-680 (Tozasertib, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with ... Cancer
T2429 GZD824 Dimesylate GZD824 Dimesylate is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) an... Cancer
T2328 Radotinib Radotinib, and sometimes referred to by its investigational name IY5511, is a drug fo... Cancer
T2293 SGX-523 SGX-523 is a selective Met inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-R... Cancer
T2116 AEE788 AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM an... Cancer
T1844 KPT-330 KPT-330 inhibited proliferation and induced cell cycle arrest and apoptosis-related p... Cancer
T1817 GNF-2 GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no activi... Other
T1803 GNF-5 GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective ... Other
T1621 Imatinib Mesylate Imatinib mesylate is a tyrosine kinase inhibitor IC50 value of 100 nM, 100 nM, 600 nM... Cancer
T1524 Nilotinib Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation a... Cancer
T1448L Dasatinib monohydrate Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved f... Cancer
T0152 Bosutinib Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-... Cancer
T6311 Bafetinib Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 o... Cancer
T6300 WP1130 Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and... Cancer
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