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Home > Chromatin/Epigenetic > Pim > AZD1208
AZD1208  
Catalog No. T2300    CAS 1204144-28-4
Pack Size
Availability
Price/USD
Quantity
10mg
In Stock
96.00
10mM * 1mL (in DMSO)
In Stock
76.00
50mg
In Stock
280.00
Bulk Size: Please Quote for Discount
Documents and Quality Management
Purity:98.00% COA Datasheet HNMR MSDS
Biological Activity:

Product Description:

AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases and is currently undergoing Phase I testing and dose escalation studies in AML. AZD1208 suppresses the growth of MOLM 16 and KG 1 xenograft tumors in vivo in a dosedependent manner. Furthermore, AZD1208 leads to potent inhibition of colony development of primary AML cells from bone marrow aspirates and downregulates the phosphorylation of PIM goals. AZD1208 inhibits the growth of several AML cell lines and sensitivity correlates with the level of PIM1 expression, STAT5 activation and presence of protein tyrosine kinase mutation. AZD1208 causes cell cycle arrest and apoptosis in MOLM-16 cells in culture.

Target:
Pim3; Pim2; Pim1;
Research Area:
Cancer
Chemical Information:
Molecular Weight 379.48
Formula C21H21N3O2S
CAS Number 1204144-28-4
Solubility DMSO: 75 mg/mL warmed (197.63 mM)
Storage 3 years -20°C powder;
2 years -80°C in solvent;
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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Reference

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