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Compound Libraries CNS-Penetrant Compound Library

CNS-Penetrant Compound Library

Catalog No. L5900
  Library Compound List   Excel SDF

The blood–brain barrier (BBB) is a highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). In its neuroprotective role, the blood–brain barrier functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain. Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders. Choosing the compounds that could penetrate BBB into the compound library targeting CNS is critical for CNS drug discovery. Based on the scientific literature, TargetMol collects 421 out of 5000 compounds as CNS-Penetrant Compound Library, which can be used for CNS-Penetrant related research and drug screening for CNS diseases.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 7007.00
250 μL * 10 mM (in DMSO) 11513.00
1 mg 11513.00
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Product Description

  • A unique collection of 421 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
  • Targets include Kinases, GPCR, and ion channels, etc.;
  • Effective tool for drug screening in brain disorders, such as brain tumor, mental disorders, and neurodegenerative diseases, etc.;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable and CNS penetrant;
  • NMR and HPLC/LCMS validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging and Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice.
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Library Composition

COX (12)
5-HT Receptor (9)
Dopamine Receptor (7)
GABA Receptor (7)
Sodium Channel (6)
Histamine Receptor (5)
c-Kit (4)
EGFR (4)
AChR (4)
Adrenergic Receptor (4)
Raf (4)
Reverse Transcriptase (4)
MRP (3)
NMDAR (3)
PDE (3)
PDGFR (3)
Bcr-Abl (3)
Calcium Channel (3)
Carbonic Anhydrase (3)
DNA/RNA Synthesis (3)
HDAC (3)
FLT (2)
GluR (2)
CDK (2)
Dehydrogenase (2)
Src (2)
VEGFR (2)
Retinoid Receptor (1)
Telomerase (1)
TNF (1)
Topoisomerase (1)
Transferase (1)
Tyrosine Kinases (1)
Phospholipase (1)
PI3K (1)
Potassium Channel (1)
PPAR (1)
Opioid Receptor (1)
Neurokinin 1 (1)
p38 MAPK (1)
P450 (1)
PARP (1)
DHFR (1)
DNA Alkylation (1)
c-Fms (1)
Chloride channel (1)
CaMK (1)
Beta Amyloid (1)
Antifungal (1)
Aromatase (1)
GR (1)
GSK-3 (1)
ERK (1)
Estrogen/progestogen Receptor (1)
HIV Protease (1)
HMG-CoA Reductase (1)
MMP (1)
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