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(1R,2R)-2-PCCA hydrochloride

(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system.

Catalog No. T13423Cas No. 1609563-71-4

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Purity:99.88%

ee:99.92%

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(1R,2R)-2-PCCA hydrochloride

Catalog No. T13423Cas No. 1609563-71-4

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$73	In Stock
2 mg	$98	In Stock
5 mg	$147	In Stock
10 mg	$289	In Stock
25 mg	$596	In Stock
50 mg	$787	In Stock
100 mg	$1,070	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock

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Product Introduction

Bioactivity

Description	(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system.
Targets&IC50	GPR88 receptor:56 nM (EC50, HEK293 cell), GPR88-22F cells:603 nM (EC50), GPR88 receptor:3 nM (EC50, cell-free assay)
In vitro	(1R,2R)-2-PCCA hydrochloride (Example 3) is an effective GPR88 receptor agonist with an EC50 of 3 nM in cell-free assay experiments and 603 nM in cellular assays[1]. Through the Gαi-coupled pathway, (1R,2R)-2-PCCA hydrochloride inhibits GPR88-mediated cAMP production, with an EC50 of 56 nM cAMP constructs in HEK293 cells stably expressing human GPR88 receptor and GloSensor-22F[1].
Alias	(1R,2R)-2-PCCA(hydrochloride)

Chemical Properties

Molecular Weight	528.56
Formula	C₃₀H₃₉Cl₂N₃O
Cas No.	1609563-71-4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 20 mg/mL (37.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8919 mL	9.4597 mL	18.9193 mL	94.5966 mL
5 mM	0.3784 mL	1.8919 mL	3.7839 mL	18.9193 mL
10 mM	0.1892 mL	0.9460 mL	1.8919 mL	9.4597 mL
20 mM	0.0946 mL	0.4730 mL	0.9460 mL	4.7298 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

(1R,2R)2PCCA hydrochloride2-PCCA(hydrochloride)2-PCCA Hydrochloride(1R,2R) 2 PCCA hydrochloride