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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $465 | In Stock | |
10 mg | $679 | In Stock | |
25 mg | $1,070 | In Stock | |
50 mg | $1,430 | In Stock | |
100 mg | $1,930 | In Stock |
Description | (1S,2R)-2-PCCA is a novel and potent small molecule GPR88 receptor agonist with an EC50 value of 3 nM in the non-cellular system and 603 nM in the cellular system. |
Targets&IC50 | GPR88 receptor:3 nM (EC50), Gαi-coupled pathway:56 nM |
In vitro | (1R,2R)-2-PCCA (Example 3) is a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay and 603 nM in cell assay[1][2]. In HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct, (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM[2]. |
Alias | (1S,2R)-2-PCCA(Iso-1609563-71-4) |
Molecular Weight | 528.56 |
Formula | C30H39Cl2N3O |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (104.06 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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