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α4 integrin receptor antagonist 3

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Catalog No. T89582Cas No. 863226-74-8

Compound 11, an α4 integrin receptor antagonist, exhibits oral activity and functions as an antagonist of the α4 integrin receptor. It efficiently inhibits the adhesion of K562 cells mediated by the interactions of α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. Compound 11 also shows potential for use in studies using the DSS (dextran sulfate sodium) induced colitis mouse model.

α4 integrin receptor antagonist 3

α4 integrin receptor antagonist 3

😃Good
Catalog No. T89582Cas No. 863226-74-8
Compound 11, an α4 integrin receptor antagonist, exhibits oral activity and functions as an antagonist of the α4 integrin receptor. It efficiently inhibits the adhesion of K562 cells mediated by the interactions of α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. Compound 11 also shows potential for use in studies using the DSS (dextran sulfate sodium) induced colitis mouse model.
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50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
Compound 11, an α4 integrin receptor antagonist, exhibits oral activity and functions as an antagonist of the α4 integrin receptor. It efficiently inhibits the adhesion of K562 cells mediated by the interactions of α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. Compound 11 also shows potential for use in studies using the DSS (dextran sulfate sodium) induced colitis mouse model.
In vitro
α4 integrin receptor antagonist 3 inhibits the adhesion of K562 cells mediated by interactions between α4β1/VCAM-1 and α4β7/MAdCAM-1.
Chemical Properties
Molecular Weight506.33
FormulaC23H21Cl2N3O6
Cas No.863226-74-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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