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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | αvβ5 integrin-IN-2 (Cpd_AV2) is an inhibitor that targets the β-propeller central pocket of ITGAV (integrin αV) and disrupts the stability of integrin heterodimers. This compound induces cellular apoptosis [1]. |
In vitro | αvβ5 integrin-IN-2 (Cpd_AV2) diminishes the presence of integrin αVβ5 on the cell surface with an IC₅₀ of approximately 6.9 μM [1]. At a concentration of 40 µM, αvβ5 integrin-IN-2 induces significant apoptosis and cell cycle arrest in MDA231 cells within 3 hours of treatment [1]. |
Molecular Weight | 480.69 |
Formula | C32H40N4 |
Cas No. | 1005104-60-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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