Shopping Cart
- Remove All
- Your shopping cart is currently empty
(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $134 | 5 days | |
25 mg | $689 | 6-8 weeks | |
50 mg | $896 | 6-8 weeks | |
100 mg | $1,350 | 6-8 weeks |
Description | (+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. |
In vitro | (+)-DHMEQ activates Nrf2, a transcription factor that can induce the expression of various antioxidant enzymes. (+)-DHMEQ activates Nrf2 in promoter reporter gene analysis. (+)-DHMEQ also increases the expression of target antioxidant proteins in nerve cell lines and eliminates reactive oxygen species (ROS)-induced cell death. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2. |
Alias | (1R,2R,6R)-DHMEQ, (1R,2R,6R)-Dehydroxymethylepoxyquinomicin |
Molecular Weight | 261.23 |
Formula | C13H11NO5 |
Cas No. | 287194-41-6 |
Relative Density. | 1.58 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (382.80 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.