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(+)-DHMEQ

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Catalog No. T13462Cas No. 287194-41-6
Alias (1R,2R,6R)-DHMEQ, (1R,2R,6R)-Dehydroxymethylepoxyquinomicin

(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.

(+)-DHMEQ

(+)-DHMEQ

😃Good
Catalog No. T13462Alias (1R,2R,6R)-DHMEQ, (1R,2R,6R)-DehydroxymethylepoxyquinomicinCas No. 287194-41-6
(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.
Pack SizePriceAvailabilityQuantity
2 mg$1345 days
25 mg$6896-8 weeks
50 mg$8966-8 weeks
100 mg$1,3506-8 weeks
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Product Introduction

Bioactivity
Description
(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.
In vitro
(+)-DHMEQ activates Nrf2, a transcription factor that can induce the expression of various antioxidant enzymes. (+)-DHMEQ activates Nrf2 in promoter reporter gene analysis. (+)-DHMEQ also increases the expression of target antioxidant proteins in nerve cell lines and eliminates reactive oxygen species (ROS)-induced cell death. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2.
Alias(1R,2R,6R)-DHMEQ, (1R,2R,6R)-Dehydroxymethylepoxyquinomicin
Chemical Properties
Molecular Weight261.23
FormulaC13H11NO5
Cas No.287194-41-6
Relative Density.1.58 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (382.80 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8280 mL19.1402 mL38.2804 mL191.4022 mL
5 mM0.7656 mL3.8280 mL7.6561 mL38.2804 mL
10 mM0.3828 mL1.9140 mL3.8280 mL19.1402 mL
20 mM0.1914 mL0.9570 mL1.9140 mL9.5701 mL
50 mM0.0766 mL0.3828 mL0.7656 mL3.8280 mL
100 mM0.0383 mL0.1914 mL0.3828 mL1.9140 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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