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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 μg | $455 | 35 days | |
50 μg | $793 | 35 days | |
100 μg | $1,530 | 35 days |
Description | Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse. It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation. |
Molecular Weight | 360.494 |
Formula | C22H32O4 |
Cas No. | 871826-47-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMF: Miscible PBS (pH 7.2): 0.5 mg/mL DMSO: Miscible 0.1 M Na2CO3: 1 mg/mL Ethanol: Miscible |
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