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diethyl-[2-(3-methoxy-N-[2-(4-propoxyphenoxy)acetyl]anilino)ethyl]azanium chloride

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Catalog No. T33143Cas No. 27471-66-5
Alias m-Acetanisidide, N-(2-(diethylamino)ethyl)-2-(p-isopropoxyphenoxy)-,monohydrochloride, m-Acetanisidide, N-(2-(diethylamino)ethyl)-2-(p-isopropoxyphenoxy)-, monohydrochloride

m-Acetanisidide, N-(2-(diethylamino)ethyl)-2-(p-isopropoxyphenoxy)-, monohydrochloride is a bioactive chemical.

diethyl-[2-(3-methoxy-N-[2-(4-propoxyphenoxy)acetyl]anilino)ethyl]azanium chloride

diethyl-[2-(3-methoxy-N-[2-(4-propoxyphenoxy)acetyl]anilino)ethyl]azanium chloride

😃Good
Catalog No. T33143Alias m-Acetanisidide, N-(2-(diethylamino)ethyl)-2-(p-isopropoxyphenoxy)-,monohydrochloride, m-Acetanisidide, N-(2-(diethylamino)ethyl)-2-(p-isopropoxyphenoxy)-, monohydrochlorideCas No. 27471-66-5
m-Acetanisidide, N-(2-(diethylamino)ethyl)-2-(p-isopropoxyphenoxy)-, monohydrochloride is a bioactive chemical.
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QWhere can I find purity infomation for future products?
AFor futures products, no purity information or quality inspection can be available. Once the products are available, we will conduct quality inspections to determine the purity and structural information, which will be displayed on our official website.
QCan inhibitors be used for animal experiments?
AYes, our inhibitors can be used for animal/in vivo experiments. However, some compounds may not have literature supporting their use in animal experiments. In such cases, we cannot guarantee efficacy.
QIs there a need to weigh and prepare stock solutions upon receiving the product?
AFor small packages(1 mg, 5 mg, 10 mg, etc.）, it is not recommended to weigh them again which may lead to compound loss and inaccurate measurement. Our products are imported in their original packaging and accurately weighed, so you can directly dissolve the compound in the appropriate solvent upon receipt. For large packages, you can weigh and prepare stock solutions. It is recommended to start with at least 10 mg to reduce error. If conditions permit, you can first prepare a high-concentration stock solution and then aliquot it for use
Qwhat frequency should sonication be used?
AIt is recommended to use the conventional ultrasound cleaning frequency
QCan the inhibitor DMSO stock solution be directly diluted with buffer to create a gradient?
AIn most cases, it can dissolve. However, sometimes organic reagents may precipitate when directly added to an aqueous medium. It is recommended to first dilute the inhibitor with DMSO to form a gradient, and then add the diluted inhibitor to the buffer or cell culture medium. Some inhibitors may only dissolve in the aqueous phase at their working concentrations. For example, if a final concentration of 1 μM is desired in cell experiments, the 10 mM DMSO stock solution can be diluted to 1 mM with DMSO, and then 2 μL can be drawn and added to 2 mL of saline/PBS/cell culture medium, resulting in a final concentration of 1 μM. To avoid precipitation of the drug, it is recommended to preheat the mother liquor and culture medium to 37°C before dilution to avoid serious precipitation caused by low temperature. If precipitation occurs during the dilution process, it is suggested to use ultrasonic heating to redissolve the compound.
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Product Introduction

Bioactivity
Description
m-Acetanisidide, N-(2-(diethylamino)ethyl)-2-(p-isopropoxyphenoxy)-, monohydrochloride is a bioactive chemical.
Aliasm-Acetanisidide, N-(2-(diethylamino)ethyl)-2-(p-isopropoxyphenoxy)-,monohydrochloride, m-Acetanisidide, N-(2-(diethylamino)ethyl)-2-(p-isopropoxyphenoxy)-, monohydrochloride
Chemical Properties
Molecular Weight451
FormulaC24H35ClN2O4
Cas No.27471-66-5
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

References

1.Scuto A, et al. SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May; 4(5): e635.2.Milne JC, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170): 712–716.

Citations

1.Qin Z, Fang X, Sun W, et al. Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity. Nature Immunology. 2022: 1-15

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

diethyl[2(3methoxyN[2(4propoxyphenoxy)acetyl]anilino)ethyl]azanium chloridediethyl [2 (3 methoxy N [2 (4 propoxyphenoxy)acetyl]anilino)ethyl]azanium chloride
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