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4-Methoxy 17β-Estradiol
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Catalog No. T9456Cas No. 26788-23-8
4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.
4-Methoxy 17β-Estradiol
😃Good
Catalog No. T9456Cas No. 26788-23-8
4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $413 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol. |
| In vitro | 4-Methoxy-17-estradiol treatment significantly decreased cell growth and increased mitotic index. Elevation of ROS and SOD activity, with a concomitant decrease in the intracellular GSH/GSSG ratio, was also detected in 4-Methoxy-17-estradiol-treated cells. Quantitative comet assay showed increased oxidative DNA damage in the 4-Methoxy-17-estradiol-treated H1355 cells, which could be significantly reduced by the anti-oxidant N-acetylcysteine (NAC)[1]. |
| In vivo | 4-Methoxy-17-estradiol had much weaker estrogenic activity and have similar lipid-modulating effects compared to 4-hydroxyestradiol in ovariectomized female rats[3]. |
| Molecular Weight | 302.41 |
| Formula | C19H26O3 |
| Cas No. | 26788-23-8 |
| Smiles | C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1c(cc1)c3c(OC)c1O)[C@H]2O |
| Relative Density. | 1.178 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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