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5-Octyl-α-ketoglutarate

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Catalog No. T36871Cas No. 1616344-00-3

In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate, also known as α-ketoglutarate octyl ester, is a stable, cell-permeable molecule that generates free α-ketoglutarate upon hydrolysis of the ester bond by cytoplasmic esterases. It is used in experiments to increase levels of intracellular α-ketoglutarate. 5-Octyl-α-ketoglutarate has been shown to modulate a variety of enzymes and signaling pathways, particularly in the context of glycolysis, hypoxia, and cancer.

5-Octyl-α-ketoglutarate

5-Octyl-α-ketoglutarate

😃Good
Catalog No. T36871Cas No. 1616344-00-3
In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate, also known as α-ketoglutarate octyl ester, is a stable, cell-permeable molecule that generates free α-ketoglutarate upon hydrolysis of the ester bond by cytoplasmic esterases. It is used in experiments to increase levels of intracellular α-ketoglutarate. 5-Octyl-α-ketoglutarate has been shown to modulate a variety of enzymes and signaling pathways, particularly in the context of glycolysis, hypoxia, and cancer.
Pack SizePriceAvailabilityQuantity
1 mgTBD35 days
5 mgTBD35 days
10 mgTBD35 days
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Product Introduction

Bioactivity
Description
In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate, also known as α-ketoglutarate octyl ester, is a stable, cell-permeable molecule that generates free α-ketoglutarate upon hydrolysis of the ester bond by cytoplasmic esterases. It is used in experiments to increase levels of intracellular α-ketoglutarate. 5-Octyl-α-ketoglutarate has been shown to modulate a variety of enzymes and signaling pathways, particularly in the context of glycolysis, hypoxia, and cancer.
Chemical Properties
Molecular Weight258.31
FormulaC13H22O5
Cas No.1616344-00-3
Relative Density.1.083 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (38.71 mM), Sonication is recommended.
Ethanol: 20 mg/mL (77.43 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (3.87 mM), Sonication is recommended.
DMF: 10 mg/mL (38.71 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM3.8713 mL19.3566 mL38.7132 mL193.5659 mL
DMSO/DMF/Ethanol
1mg5mg10mg50mg
5 mM0.7743 mL3.8713 mL7.7426 mL38.7132 mL
10 mM0.3871 mL1.9357 mL3.8713 mL19.3566 mL
20 mM0.1936 mL0.9678 mL1.9357 mL9.6783 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

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