5-Methylresorcinol monohydrate (Orcinol monohydrate) serves as a tyrosinase inhibitor and demonstrates cytotoxic properties. Additionally, it is an orally active anxiolytic agent that can cross the blood-brain barrier [1] [2].

5-Methylresorcinol monohydrate (Orcinol monohydrate), administered at concentrations of 100, 200, and 500 µM over periods of 24 and 72 hours, exhibited cytotoxic effects on B16 and Hs68 cell lines. According to the Cell Cytotoxicity Assay, it resulted in an inhibition rate of 101.7% in Hs68 cells at 24 hours and 104.4% in B16 cells at 72 hours.

5-Methylresorcinol monohydrate, administered orally at doses of 2.5 and 5 mg/kg, exhibits anti-anxiety properties without producing sedation [2]. In studies using male CD-1 mice weighing 18-22 g [2], this compound increased both the duration and frequency of open arm entries in the elevated plus-maze test, as well as the number of head-dips in the hole-board test. Importantly, it did not significantly alter the locomotor activity in the open-field test.