6'-Methyl paeonol, a derivative of paeonol, inhibits abnormal depolarizations and reduces Amyloid β-induced ERK phosphorylation, exhibiting activity that alleviates Alzheimer’s Disease [1].

6'-Methyl paeonol (0.1-100 μM) demonstrates inhibitory effects on NMDA and AMPA-mediated neuronal depolarization, thus mitigating Aβ-driven abnormal depolarization. Western Blot Analysis [1] revealed that in the C2C12 cell line, a concentration of 100 μM with an incubation time of 2 hours reversed the Aβ-induced increase in ERK phosphorylation.

Administered subcutaneously at a dosage of 20 mg/kg, '6'-Methyl paeonol significantly enhanced the ability of J20 mice to locate a hidden platform in experiments, thereby effectively improving their learning and memory functions [1]. The model used was the APP transgenic C57BL/6 mouse (J20 mice) [1], and the method of administration was a subcutaneous injection at a dose of 20 mg per kilogram of body weight. The study results indicated a reduced time for the mice to find the hidden platform.