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8-Br-7-CH-ADPR

Catalog No. T89123Cas No. 1011457-95-6
Alias 8-Bromo-7-deazaadenosine-5'-O-diphosphoribose

8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5-O-diphosphoribose) serves as a specific antagonist of TRPM2, functioning by binding to the NUDT9 homology domain within the TRPM2 channel, inhibiting its activation, and subsequently regulating the influx of cations through the cell membrane channel. This compound is utilized in research to explore the role of TRPM2 in processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes.

8-Br-7-CH-ADPR

8-Br-7-CH-ADPR

Catalog No. T89123Alias 8-Bromo-7-deazaadenosine-5'-O-diphosphoriboseCas No. 1011457-95-6
8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5-O-diphosphoribose) serves as a specific antagonist of TRPM2, functioning by binding to the NUDT9 homology domain within the TRPM2 channel, inhibiting its activation, and subsequently regulating the influx of cations through the cell membrane channel. This compound is utilized in research to explore the role of TRPM2 in processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes.
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5-O-diphosphoribose) serves as a specific antagonist of TRPM2, functioning by binding to the NUDT9 homology domain within the TRPM2 channel, inhibiting its activation, and subsequently regulating the influx of cations through the cell membrane channel. This compound is utilized in research to explore the role of TRPM2 in processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes.
Alias8-Bromo-7-deazaadenosine-5'-O-diphosphoribose
Chemical Properties
Molecular Weight637.22
FormulaC16H23BrN4O14P2
Cas No.1011457-95-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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