Shopping Cart

Remove All
Your shopping cart is currently empty

AZM475271

Name: AZM475271
Brand: TargetMol
SKU: T14487
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T14487Cas No. 476159-98-5

Alias M475271

AZM475271 is a potent and selective inhibitor of Src kinase (IC50: 5 nM).

AZM475271

Purity: 99.78%

Catalog No. T14487Alias M475271Cas No. 476159-98-5

AZM475271 is a potent and selective inhibitor of Src kinase (IC50: 5 nM).

Pack Size	Price	Availability	Quantity
2 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock

Bulk & Custom

Add to Cart

Questions

Select Batch

Purity:99.78%

Resource Download

COA HNMR HPLC

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	AZM475271 is a potent and selective inhibitor of Src kinase (IC50: 5 nM).
In vitro	AZM475271 demonstrated strong dose-dependent inhibition of Src tyrosine kinase activity in the L3.6pl human pancreatic carcinoma cell line. The IC50 concentration of AZM475271 to inhibit the phosphorylation of c-src, lck, and c-yes was 0.01, 0.03, and 0.08 μmol/L, respectively, in comparison with an IC50 of 0.7 μmol/L AZM475271 to inhibit KDR [2]. Maximum reduction of Src kinase activity was observed after incubation for 4 hours with ≥5 μmol/L.
In vivo	Treatment with gemcitabine or AZM475271 alone did not significantly change animal weight [2]. In vivo: Tumors appeared to be palpable at day 14 after tumor cell injection in all animals except mice treated with both AZM475271 and gemcitabine, in which the earliest possible palpation of the tumors was at day 17 after tumor cell injection.
Alias	M475271

Chemical Properties

Molecular Weight	442.94
Formula	C₂₃H₂₇ClN₄O₃
Cas No.	476159-98-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 42 mg/mL (94.82 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2576 mL	11.2882 mL	22.5764 mL	112.8821 mL
5 mM	0.4515 mL	2.2576 mL	4.5153 mL	22.5764 mL
10 mM	0.2258 mL	1.1288 mL	2.2576 mL	11.2882 mL
20 mM	0.1129 mL	0.5644 mL	1.1288 mL	5.6441 mL
50 mM	0.0452 mL	0.2258 mL	0.4515 mL	2.2576 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

M 475271AZM 475271AZM475271AZM-475271M-475271