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Beclomethasone 17-propionate

Catalog No. T10494 CAS 5534-18-9

Synonyms: Beclomethasone-17-monopropionate, 17-BMP

Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in COPD lung macrophages.

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Beclomethasone 17-propionate Chemical Structure

Beclomethasone 17-propionate, CAS 5534-18-9

Pack Size	Availability	Price/USD
2 mg	5 days	$ 119.00
5 mg	5 days	$ 198.00
10 mg	5 days	$ 372.00
25 mg	5 days	$ 788.00
1 mL * 10 mM (in DMSO)	5 days	$ 198.00

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Description	Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in COPD lung macrophages.
In vitro	Beclomethasone 17-propionate inhibits LPS-stimulated CXCL8, TNFα, and IL-6. The EC50 values of Beclomethasone 17-propionate for IL-6, TNFα, and CXCL8 were 0.05 nM, 0.01 nM, and 0.1 nM, respectively. Beclomethasone 17-propionate evokes the upregulation of the GR dependent genes FKBP51 and GILZ [3].

Synonyms	Beclomethasone-17-monopropionate, 17-BMP
Molecular Weight	464.98
Formula	C25H33ClO6
CAS No.	5534-18-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Würthwein G, et al. Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate. Biopharm Drug Dispos. 1990 Jul;11(5):381-94. 2. Roberts JK, et al. Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther. 2013 May;345(2):308-16. 3. Plumb J, et al. Evaluation of glucocorticoid receptor function in COPD lung macrophages using beclomethasone-17-monopropionate. PLoS One. 2013 May 21;8(5):e64257.

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Keywords

Beclomethasone 17-propionate 5534-18-9 Others Beclomethasone-17-monopropionate Beclomethasone Beclomethasone 17 propionate 17-BMP Beclomethasone 17propionate inhibitor inhibit

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